Search results for "Amorphous solid dispersion"

showing 2 items of 2 documents

Development and Characterization of an Amorphous Solid Dispersion of Furosemide in the Form of a Sublingual Bioadhesive Film to Enhance Bioavailabili…

2017

Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoadhesive sublingual fast-dissolving FUR based film has been developed and evaluated in order to optimize the bioavailability of FUR by increasing solubility and guaranteeing a good dissolution reproducibility. The Differential Scanning Calorimetry (DSC) analyses confirmed that the film prepared using the solvent casting method entrapped FUR in the amorphous state. As a solid dispersion, FUR increa…

Absorption (pharmacology)medicine.medical_specialtymucoadhesive filmMaterials scienceBioadhesivePharmaceutical Sciencelcsh:RS1-44102 engineering and technology030226 pharmacology & pharmacyArticleSublingual Absorptionlcsh:Pharmacy and materia medica03 medical and health sciences0302 clinical medicineDifferential scanning calorimetryamorphous solid dispersiontransmucosal deliverymedicineSolubilityDissolutionAmorphous solid dispersion; Furosemide bioavailability; Mucoadhesive film; Sublingual absorption; Transmucosal delivery;021001 nanoscience & nanotechnologyfurosemide bioavailabilityAmorphous solidSurgeryBioavailabilitysublingual absorptionChemical engineeringSettore CHIM/09 - Farmaceutico Tecnologico Applicativomucoadhesive film; sublingual absorption; amorphous solid dispersion; furosemide bioavailability; transmucosal delivery0210 nano-technologyPharmaceutics
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3D-Printed Solid Dispersion Drug Products.

2019

With the well-known advantages of additive manufacturing methods such as three-dimensional (3D) printing in drug delivery, it is disappointing that only one product has been successful in achieving regulatory approval in the past few years. Further research and development is required in this area to introduce more 3D printed products into the market. Our study investigates the potential of fixed dose combination solid dispersion drug products generated via 3D printing. Two model drugs&mdash

Drug3d printedMaterials sciencemedia_common.quotation_subjecteducationPharmaceutical Science3D printing02 engineering and technology030226 pharmacology & pharmacyPolyvinyl alcoholArticle03 medical and health scienceschemistry.chemical_compound0302 clinical medicineamorphous solid dispersionfixed dose combinationmedia_commonbusiness.industry3D printing021001 nanoscience & nanotechnologySolventpoor solubilitychemistryChemical engineeringDrug deliveryManufacturing methods0210 nano-technologybusinessDispersion (chemistry)additive manufacturingPharmaceutics
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